Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 May 27;286(28):24957–24965. doi: 10.1074/jbc.M111.221416

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 4. — D₄ reduces microtubule stability in high activity PFC pyramidal neurons via a mechanism dependent on CaMKII and MAP2. A, immunoblots and quantification of free tubulin showing the effect of PD168077 treatment (40 μm, 10 min) on microtubule depolymerization in PFC cultures pretreated without or with bicuculline (Bic; 10 μm, 2 h). *, p < 0.001, ANOVA. B, immunoblots and quantification of free tubulin showing the effect of PD168077 on microtubule depolymerization in PFC cultures (bicuculline-pretreated) infected with GFP versus constitutively active CaMKII Sindbis virus, or treated with MAP2 antisense versus sense oligonucleotides (1 μm). Free tubulin was normalized to GFP-infected neurons in the absence of PD168077. *, p < 0.001, ANOVA.