Table 2.
Opposite Direction of p53- and NF-κB-Driven Responses
| p53 | NF-κB |
|---|---|
| Sensor and mediator of intrinsic stresses | Sensor and mediator of extrinsic stresses |
| Tumor suppressor frequently inactivated in cancer | Oncogene frequently activated in tumors |
| Growth suppressive, pro-apoptotic | Growth stimulating, anti-apoptotic |
| Long-term inactivation leads to cancer | Long-term activation leads to cancer |
| Anticancer context: target for activation | Anticancer context: target for repression |
| Tissue protection context: target for repression | Tissue protection context: target for activation |