Table 1.
| 1a: Description of participants by mid-life migraine status: Men (n=1996) from the AGES-Reykjavik Study | ||||
|---|---|---|---|---|
| Headache Status | No headache n=1589 |
Non- Migraine Headache n=294 |
Migraine Without Aura n=30 |
Migraine With Aura n=83 |
| Age (years) at Mid-Life Exam | 49.9 (±5.7) | 49.3 (±6.1) | 48.3 (±5.1) | 47.6 (±5.7) |
| Age (years) at Late-Life Exam | 76.6 (±5.3) | 76.0 (±5.4) | 75.0 (±3.9) | 74.6 (±4.9) |
| Follow up time (years) | 26.7 (±3.1) | 26.6 (±3.1) | 26.7 (±2.5) | 27.0 (±2.7) |
| Mid-Life (Interview 1) Risk Profile | ||||
| Primary education (%) | 358 (22.5%) | 71 (24.2%) | 5 (16.7%) | 24 (28.9%) |
| Current smoking (%) | 724 (45.6%) | 131 (44.6%) | 12 (40.0%) | 42 (50.6%) |
| Fasting glucose (mg/dl)* | 80.3 (±10.0) | 79.2 (±9.5) | 81.2 (±8.7) | 81.3 (±21.9) |
| Cholesterol level (mmol/l)* | 6.4 (±1.0) | 6.3 (±1.0) | 6.1 (±0.8) | 6.2 (±1.0) |
| BMI* | 25.5 (±3.1) | 25.4 (±3.1) | 25.5 (±3.0) | 25.9 (±3.3) |
| Diabetes (%) | 11 (0.7%) | 4 (1.4%) | 0 (0.0%) | 1 (1.2%) |
| Mean systolic BP (mmHg)* | 135.2 (±15.8) | 134.3 (±16.6) | 131.4 (±10.0) | 132.4 (±13.0) |
| Antihypertensive medication use (%) | 57 (3.6%) | 13 (4.4%) | 1 (3.3%) | 4 (4.8%) |
| Late-Life (Interview 2) Risk Profile | ||||
| Coronary calcification top quartile (%) | 387 (24.6%) | 70 (24.1%) | 9 (31.0%) | 24 (29.6%) |
| Carotid artery distensibility (bottom quartile) (%) | 385 (25.3%) | 70 (24.8%) | 5 (17.2%) | 25 (32.1%) |
| Diabetes (%) | 235 (14.8%) | 39 (13.3%) | 6 (20.0%) | 16 (19.3%) |
| Current smoking (%) | 260 (16.4%) | 46 (15.7%) | 6 (20.0%) | 17 (20.7%) |
| Mean systolic BP (mmHG)* | 143.0 (±20.2) | 143.5 (±18.8) | 142.0 (±18.3) | 145.6 (±21.1) |
| Antihypertensive medication use (%) | 979 (61.6%) | 179 (60.9%) | 22 (73.3%) | 53 (63.9%) |
| History of coronary artery disease (%) | 558 (39.7%) | 112 (41.3%) | 16 (57.1%) | 38 (48.7%) |
| History of stroke / TIA (%) | 144 (9.4%) | 33 (11.5%) | 6 (20.0%) | 7 (9.0%) |
| 1b: Description of participants by mid-life migraine status: Women (n=2693) from the AGES-Reykjavik Study | ||||
|---|---|---|---|---|
| Headache Status | No headache n=1654 |
Non-Migraine Headache n=582 |
Migraine Without Aura n=179 |
Migraine With Aura n=278 |
| Age (years) at Mid-Life Exam | 52.5 (±6.1) | 50.7 (±6.4) | 49.2 (±6.2) | 50.5 (±6.1) |
| Age (years) at Late-Life Exam | 76.7 (±5.4) | 75.3 (±5.2) | 74.2 (±4.8) | 75.1 (±5.3) |
| Follow up time (years) | 24.2 (±4.1) | 24.6 (±4.4) | 25.0 (±4.3) | 24.7 (±4.0) |
| Mid-Life (Interview 1) Risk Profile | ||||
| Primary education (%) | 710 (42.9%) | 244 (41.9%) | 69 (38.6%) | 122 (43.9%) |
| Current smoking (%) | 532 (32.2%) | 171 (29.4%) | 40 (22.4%) | 87 (31.3%) |
| Fasting glucose (mg/dl)* | 76.9 (±9.1) | 76.5 (±9.1) | 78.1 (±14.7) | 76.5 (±10.6) |
| Cholesterol level (mmol/l)* | 6.4 (±1.1) | 6.3 (±1.2) | 6.1 (±1.1) | 6.3 (±1.2) |
| BMI* | 24.8 (±3.6) | 25.0 (±4.1) | 24.9 (±3.8) | 24.7 (±3.5) |
| Diabetes (%) | 14 (0.9%) | 1 (0.2%) | 3 (1.7%) | 6 (2.2%) |
| Mean systolic BP (mmHg)* | 129.2 (±17.1) | 130.6(±17.5) | 130.8 (±16.5) | 126.4 (±14.7) |
| Antihypertensive medication use (%) | 115 (7.0%) | 57 (9.8%) | 11 (6.2%) | 24 (8.6%) |
| Late-Life (Interview 2) Risk Profile | ||||
| Coronary calcification top quartile (%) | 421 (25.7%) | 125 (21.6%) | 26 (14.5%) | 60 (21.8%) |
| Carotid artery distensibility (bottom quartile) (%) | 398 (25.4%) | 121 (21.7%) | 58 (34.1%) | 55 (20.8%) |
| Diabetes (%) | 141 (8.5%) | 53 (9.1%) | 23 (12.9%) | 25 (9.0%) |
| Current smoking (%) | 209 (12.7%) | 69 (11.9%) | 19 (10.6%) | 41 (14.8%) |
| Mean systolic BP (mmHG)* | 141.8 (±20.8) | 141.4 (±20.6) | 144.1 (±21.7) | 140.0 (±17.5) |
| Antihypertensive medication use (%) | 1007 (60.9%) | 385 (66.2%) | 122 (68.2%) | 190 (68.4%) |
| History of coronary artery disease (%) | 313 (20.7%) | 130 (23.9%) | 37 (21.9%) | 83 (31.3%) |
| History of stroke / TIA (%) | 100 (6.2%) | 37 (6.5%) | 8 (4.6%) | 26 (9.8%) |
Migraine symptoms asked of those reporting headache once or more per month, included photophobia, nausea, unilateral location, visual disturbance during / just before headache, unilateral numbness during / just before headache
Subjects are classified according to headache symptoms into four mutually exclusive categories:
| No headache | Does not have headache once or more per month |
| Non-migraine headache | Headaches with no more than one associated symptom |
| Migraine without aura (MO) | Headaches with two or three of photophobia, nausea, unilateral location |
| Migraine with aura (MA) | Headaches with visual and/or sensory aura |
Those with aura and non-aura symptoms are included in the aura category.
*
Mean ±SD; SI conversion factors; to convert glucose to mmol/l, divide by 18 (or multiply by 0.055); To convert cholesterol to mg/dl, divide by 0.02586 (or multiply by 38.67)