Table 1.
Association of LCE3C_LCE3B-del with Psoriasis in 2,832 Caucasian Subjects from Different Populations
| Population (samples) | Phenotype | Alleles | LCE3C_LCE3B-del (%) | LCE3C_LCE3B (%) | OR 95%CI | P-value |
|---|---|---|---|---|---|---|
| Spanish (557) | Psoriasis | 350 | 225 (64) | 125 (36) | 1.47 (1.28–1.72) | 0.0028 |
| Control | 764 | 420 (55) | 344 (45) | |||
|
| ||||||
| Italian replicate (900) | Psoriasis | 900 | 573 (64) | 327 (36) | 1.30 (1.12–1.51) | 0.006 |
| Control | 900 | 516 (57) | 384 (43) | |||
|
| ||||||
| Dutch replicate (484) | Psoriasis | 408 | 281 (69) | 127 (31) | 1.50 (1.29–1.74) | 0.0033 |
| Control | 560 | 334 (60) | 226 (40) | |||
|
| ||||||
| USA replicate (890) | Psoriasis | 1,192 | 847 (71) | 345 (29) | 1.36 (1.18–1.58) | 0.0038 |
| Control | 588 | 378 (64) | 210 (36) | |||
|
| ||||||
| Total (2,831) | Psoriasis | 2,852 | 1,926 (68) | 924 (32) | 1.38 (1.19–1.61) | 1.38E-08 |
| Control | 2,812 | 1,648(59) | 1,164(41) | |||
Odds ratio (OR) and 95% confidence interval 95% (CI) for LCE3C_LCE3B deleted allele (LCE3C_LCE3B-del) and psoriasis were obtained by logistic regression, overall and separately for each of the four populations; Overall OR and p-values are standardized by population according to a logistic model in which population was introduced as a confounding variable after (non-significant) heterogeneity was detected by population.