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Celecoxib causes downregulation of surface-expressed PD-1 on T cells. (A) MFI of PD-1 on CD4+ and CD8+ T cells (top row), activated CD8+ T cells (HLA-DR+/− CD38+; second row), and CCR7− CD27− and CCR7+ CD27+ CD8+ memory T cell subsets (third row). (B) Percentages of PD-1-positive cells among Gag- and Env-specific CD8+ T cells at 0 and 12 weeks in both study arms, as indicated. Median values and interquartile ranges (25th to 75th percentiles) are indicated.
