Table 4.
Linear regression analyses for association between quantitative RRB traits and SLC25A12 SNPs after controlling for age, gender, population and FSIQ in the SSC sample
| Sample | SSC sample (n = 720 probands) | ||
|---|---|---|---|
| SNP | rs2056202 (na = 714) | rs908670 (n = 712) | rs2292813 (n = 714) |
| Risk allele (frequency) | A (0.151) | G (0.291) | A (0.102) |
| Stereotyped behavior | |||
| βb | 0.655 | -0.444 | 0.211 |
| Statc | 2.883 | -2.499 | 0.783 |
| EMP1d | 0.005 | 0.012 | 0.441 |
| Permutation p | 0.012e | 0.033e | 0.763 |
| Self-injurious behavior | |||
| βb | 0.484 | -0.468 | 0.044 |
| Statc | 2.408 | -2.990 | 0.183 |
| EMP1d | 0.016 | 0.003 | 0.857 |
| Permutation p | 0.044e | 0.008e | 0.995 |
| Compulsive behavior | |||
| βb | 0.531 | -0.356 | 0.055 |
| Statc | 1.915 | -1.651 | 0.169 |
| EMP1d | 0.057 | 0.096 | 0.872 |
| Permutation P | 0.132 | 0.230 | 0.996 |
| Ritualistic behavior | |||
| βb | 0.491 | -0.114 | 0.183 |
| Statc | 1.749 | -0.519 | 0.551 |
| EMP1d | 0.077 | 0.606 | 0.573 |
| Permutation p | 0.186 | 0.904 | 0.889 |
| Sameness behavior | |||
| βb | 1.222 | -0.377 | 0.975 |
| Statc | 2.797 | -1.095 | 1.880 |
| EMP1d | 0.005 | 0.280 | 0.061 |
| Permutation p | 0.014e | 0.548 | 0.151 |
| Restricted behavior | |||
| βb | 0.579 | -0.188 | 0.469 |
| Statc | 2.953 | -1.223 | 2.019 |
| EMP1d | 0.003 | 0.220 | 0.042 |
| Permutation p | 0.008e | 0.462 | 0.107 |
| Sum | |||
| βb | 3.485 | -1.889 | 1.615 |
| Statc | 2.784 | -1.937 | 1.096 |
| EMP1d | 0.005 | 0.057 | 0.276 |
| Permutation p | 0.015e | 0.135 | 0.546 |
aNumber of subjects with non-missing genotype data available.
bStandardized regression coefficient (negative value indicates negative correlation).
cCoefficient t-statistics.
dUncorrected single-point p value.
Permutation p value: eP< 0.05.