Table 2.
Association results
| Power GER/GR | Gene | SNP | GER | GR | Combined analysis | ||||||||
| MAF (Ca/Co) | Pnom | Pcorrected | OR (95% CI) | MAF (Ca/Co) | Pnom | Pcorrected | OR (95% CI) | Pnom | Pcorrected | OR (95%) | |||
| 98%/95% | MEIS1 | rs6710341 | 0.17/0.14 | 0.282 | 0.877 | 1.2 (0.86 to 1.66) | 0.15/0.18 | 0.242 | 0.911 | 0.79 (0.54 to 1.17) | 0.891 | 1 | 1.02 (0.80 to 1.30) |
| rs12469063 | 0.31/0.23 | 0.002 | 0.013 | 1.52 (1.17 to 1.98) | 0.23/0.26 | 0.305 | 0.961 | 0.84 (0.60 to 1.17) | 0.086 | 0.421 | 1.20 (0.97 to 1.47) | ||
| rs2300478 | 0.31/0.24 | 0.004 | 0.026 | 1.47 (1.13 to 1.92) | 0.23/0.25 | 0.355 | 0.979 | 0.86 (0.62 to 1.19) | 0.110 | 0.512 | 1.18 (0.96 to 1.45) | ||
| 85%/74% | BTBD9 | rs3923809 | 0.25/0.34 | 0.001 | 0.009 | 1.55 (1.19 to 2.04) | 0.28/0.36 | 0.080 | 0.525 | 1.33 (0.97 to 1.82) | 0.0002 | 0.0013 | 1.47 (1.20 to 1.79) |
| 76%/65% | MAP2K5/SKOR1 | rs11635424 | 0.31/0.34 | 0.168 | 0.677 | 1.2 (0.93 to 1.56) | 0.34/0.39 | 0.115 | 0.659 | 1.26 (0.95 to 1.68) | 0.040 | 0.235 | 1.22 (1.01 to 1.48) |
| rs3784709 | 0.31/0.35 | 0.238 | 0.814 | 1.17 (0.90 to 1.52) | 0.34/0.38 | 0.021 | 0.175 | 1.41 (1.05 to 1.90) | 0.017 | 0.106 | 1.27 (1.04 to 1.54) | ||
| rs1026732 | 0.30/0.34 | 0.294 | 0.889 | 1.15 (0.89 to 1.50) | 0.31/0.38 | 0.069 | 0.467 | 1.31 (0.98 to 1.74) | 0.049 | 0.280 | 1.21 (1.00 to 1.47) | ||
| rs6494696 | 0.31/0.34 | 0.259 | 0.846 | 1.16 (0.9 to 1.51) | 0.34/0.39 | 0.069 | 0.467 | 1.31 (0.98 to 1.74) | 0.043 | 0.240 | 1.22 (1.01 to 1.48) | ||
| 69%/56% | PTPRD | rs1975197 | 0.15/0.18 | 0.278 | 0.871 | 0.84 (0.61 to 1.15) | 0.16/0.18 | 0.781 | 1 | 0.95 (0.66 to 1.37) | 0.273 | 0.876 | 0.87 (0.68 to 1.11) |
| rs4626664 | 0.14/0.13 | 0.687 | 1 | 1.08 (0.75 to 1.54) | 0.08/0.09 | 0.856 | 1 | 1.05 (0.64 to 1.71) | 0.713 | 1 | 1.06 (0.79 to 1.41) | ||
Loci are ordered according to the power of the study to detect the effects, based on allele frequencies and ORs found in previous studies.7 8 11
Ca, cases; Co, controls; MAF, minor allele frequency; Pnom, nominal p value from logistic regression analysis with age and gender as covariates. For the combined analysis, country of origin was added as an additional covariate. Pcorrected, p value corrected for multiple testing, empirical p value obtained from permutation.
ORs were obtained from logistic regression analysis and refer to the risk allele. Significant associations are highlighted in bold print.