Figure 2. Network integration: the interface between different types of reconstructions.
The ultimate goal of network reconstruction is to fully represent every component of the cell and define the interactions between them. Reconstruction of metabolism, transcriptional regulation, and transcription and translation networks is currently possible (as outlined in the text), with the most emphasis, to date, on metabolic reconstruction. Incorporation of small RNAs and two-component signaling interactions are future areas of reconstruction where reconstruction technologies and development are needed. For integration of networks, the interplay between each of the processes needs to be defined to fully connect each of the major cellular functions.