Figure 5.
Hippocampal LTP in the CA1 region and in the dentate gyrus is unchanged in CREB mutant mice. LTP could be induced and maintained in all groups investigated, that is, in wild-type (○), CREBαΔ (•), and CREBcomp (█) mice, irrespective of whether a single weak (A) or a repeated strong tetanization protocol (B,C) was applied. Statistical significant differences between the groups can be neither detected in the initial magnitude of potentiation nor in the maintanance (sample size for wild-type, CREBαΔ, and CREBcomp animals: weak tetanus CA1, n = 9, n = 5, n = 5, respectively; strong tetanus CA1: n = 9, n = 9, n = 5; strong tetanus dentate gyrus, n = 9, n = 9, n = 7). In all CA1 experiments, potentials from a second independent, nontetanized control input were recorded. No influence on baseline potentials was observed during the recorded period.