Figure 5.
Impaired LTPNMDA in mGluR5 mutants responding to ACPD. (a) Bath perfusions of 60 μm 1S,3R-ACPD for 5 min (horizontal bar) evoked a large initial depression followed by a parallel long-lasting potentiation of the dual components of EPSCs [LTPAMPA (•) and LTPNMDA (○) (at − 50 mV) in the wild-type mice (+/+) (n = 12). (b) In the mutants (−/−) IS-3R-ACPD produced a small initial inhibition of EPSCs followed by a single LTPAMPA (•) without LTPNMDA (○). Thirty minutes after LTP expression, 50 μm AP5 was applied for 5 min to isolate the NMDA component (13 mice per group). Superimposed traces were taken at the indicated points on the x-axis.