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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Brain Res Rev. 2010 Oct 21;67(1-2):1–39. doi: 10.1016/j.brainresrev.2010.10.003

Table 1.

NTF NTFR(s) Motoneuron Subtype Affected during Developmental PCD in KO mice
GDNF GFRα1; Ret Brachial: LD,CM - Ingrowth 171,172; Lumbar: Peroneal – Choicepoint173; sGM / TFL, iPsM - Ingrowth51 All spinal levels: 20–30% loss51, 113, 161–163; γ MNs (~90% loss)51; Facial: ~20% loss: Yes163; No161, 162, 174
Neurturin GFRα2, Ret Spinal and cranial levels: No deficits noted in Neurturin KO or GFRα2 KO mice*
BDNF, NT-4/5 TrkB; p75 Spinal and cranial levels: No deficits noted in BDNF KO36, 187–189, NT-4/5 KO187–189, TrkB KO190; p75 KO149
NT-3 TrkC; p75 NT-3 KOs: All spinal levels: γ MNs (complete loss)51, 192,195; Facial MNs: No deficits37,39
CNTF CNTFRα; LIFRβ; gp130 CNTF or LIF KOs: Spinal and cranial levels: No deficits; CNTFRα223; LIFRβ224; gp130225 KOs: ~40% loss
LIF LIFRβ; gp130 Same as above
CT-1 LIFRβ; gp130 CT-1 KO: All spinal levels: 20–30% loss226; Facial: ~20% loss,226; Hypoglossal: ~20% loss226
CLC/CLF CNTFRα; LIFRβ; gp130 CLC/CLF KO: Spinal levels: Lumbar (25% loss); Brachial55, Thoracic (No loss); Facial: - ~30% loss55; Hypoglossal: No loss55
HGF Met Met KO: Brachial: LD,CM - Ingrowth239; Spinal and cranial levels: MN counts NE (embryonic lethality)
IGF-I, IGF-II IGFR-1,IGFR-2 IGF-I KO: Spinal levels: ~30 loss**; Facial: ~25% loss256; Trigeminal: ~30% loss256; IGR-1,2 KOs NEbut see 59
VEGF Flk-I;Flt-1;Flt-4 VEGF KO: Facial: Migration267; Spinal and cranial levels: MN counts NE (embryonic lethality)