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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Cancer Res. 2011 Apr 15;71(11):3991–4001. doi: 10.1158/0008-5472.CAN-10-3175

Figure 4. ALDH+CD133+ cells identify poor risk tumors.

Figure 4

(A) Representative Immunofluorescent classification of ovarian tumors as ALDH+/−CD133+/−; ALDH is stained in green and CD133 in red. Scale bars indicate 100 micrometers. (Bi and ii) Kaplan-Meier analysis of overall and recurrence free survival in 56 patients whose tumors were scored as either ALDH−CD133− (n=4), ALDH+CD133− (n=26), ALDH−CD133+ (n=8), or ALDH+CD133+ (n=18). See methods for scoring methodology. (C) Proposed model for ovarian cancer stem cell differentiation. We speculate an ALDH+CD133+ CSC gives rise to an ALDH+CD133− transient amplifying cell (TAC). This cell subsequently gives rise to an ALDH−CD133− late TAC. The ability to self replicate is indicated by semi-circular arrow, with cells on the left having greatest self-renewal capacity and cells to the right having minimal self-renewal capacity.