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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2011 Mar 12;127(6):1457–1465. doi: 10.1016/j.jaci.2011.01.056

Table I.

Meta-analysis results of 34 SNPs in HHIP region in five asthmatic populations.

ppFEV1 ppFVC FEV1/FVC
No. SNP Minor (risk)
Allele C/A§ 		Coordinate Location Pmeta* Pmeta_C† Pmeta_A‡ Pmeta* Pmeta_C† Pmeta_A‡ Pmeta* Pmeta_C† Pmeta_A‡
1 rs4362772 C 145549252 5UTR
2 rs749316 G 145590796 0.029 7.3E-03 0.752 0.046 0.047 0.597 0.734 0.437 0.478
3 rs7684769 T 145638960
4 rs12641251 G/A 145644293
5 rs6827794 T 145649747
6 rs1512282 C 145650947
7** rs6845536 C (C) 145672233 2.8E-04 1.1E-04 0.600 2.5E-04 3.2E-04 0.288 0.109 0.077 0.911
8** rs720485 C (A) 145682038 4.4E-04 2.6E-03 0.067 1.1E-04 1.2E-03 0.035 0.141 0.201 0.462
9** rs1828591 G (A) 145700230 1.5E-04 1.6E-03 0.036 8.6E-05 1.2E-03 0.023 0.175 0.140 0.901
10** rs1512288 T (C) 145710731 9.6E-05 9.5E-03 7.7E-04 3.2E-05 4.5E-03 5.1E-04 0.112 0.214 0.300
11 rs2175586 A 145716391
12 rs1996020 C 145730644
13 rs7670758 A 145731325 0.0 10 1.8E-04 0.149 6.9E-03 1.8E-04 0.224 0.242 0.090 0.510
14 rs7677662 G 145732503
15 rs2353397 C 145737028 0.022 5.9E-03 0.820 0.044 0.012 0.701 0.086 0.089 0.640
16 rs4835180 G 145740058
17 rs2035901 G/A 145741317 0.340 0.232 0.854 0.054 0.033 0.920 0.721 0.485 0.593
18 rs11947381 T 145757300 0.851 0.651 0.232 0.022 1.8E-03 0.356 0.097 0.100 0.651
19 rs2575570 T 145768383
20 rs1398244 T 145781907 0.258 0.464 0.314 0.734 0.600 0.804 0.005 0.007 0.355
21 rs6845999 T 145785276
22 rs1812175 T 145794294 intron
23 rs2220514 T 145796008
24 rs2306924 A 145801986
25 rs6537307 G 145821313
26 rs2575580 C 145824475 0.936 0.600 0.270 0.270 0.929 0.033 0.099 0.132 0.496
27 rs6537310 T 145856182 0.275 0.108 0.523 0.074 7.3E-03 0.240 0.996 0.934 0.872
28 rs6854783 G 145862529 0.264 0.107 0.552 0.055 7.3E-03 0.373 0.960 0.895 0.729
29 rs11944404 C 145890321 3UTR 0.034 0.142 0.088 0.297 0.535 0.300 0.133 0.211 0.396
30 rs4835186 T 145906597
31 rs2353934 T 145916490 0.446 0.911 0.173 0.125 0.516 0.045 0.928 0.876 0.922
32 rs12647866 C 145928136
33 rs12651029 A 145989617 0.040 0.020 0.963 0.013 3.2E-03 0.822 0.852 0.651 0.662
34 rs13102609 T 145990671

Only rows with at least one entry with P value less than 0.05 are showed.

*

Pmeta is the meta-analysis P value for all five asthmatic populations.

†

Pmeta_C is the meta-analysis P value for three non-Hispanic White populations.

‡

Pmeta_A is the meta-analysis P value for two African American populations.

§

Minor (risk) Allele C/A represents minor (risk) allele of non-Hispanic White and African American populations, respectively. Risk alleles are labeled for SNPs 7-10 only. Please refer to Table E2 and E3 for other risk alleles.

**

SNPs 7-10 are the four SNPs studied for strict replication since they are in strong LD with the previously identified SNP. Results from the other previously genotyped SNPs are presented for completeness but are the results of a secondary analysis.