Figure 7.
Reduction in neurogenesis results in impaired spatial learning and memory in the Morris water maze and impaired cognitive recovery after traumatic brain injury. A–D, Morris water maze probe trial. *p < 0.05, **p < 0.01 compared with Injured + Gan (post hoc Tukey's tests). #p < 0.05, ##p < 0.01, ###p < 0.001 compared with target quadrant for A or target platform for B and C (planned comparisons within each group). A, Percentage of time spent swimming in each quadrant of the maze. The target quadrant is the quadrant in which the hidden platform was previously located, and the dotted horizontal line represents chance performance (i.e., 25% of time spent in a quadrant). B, Number of times that mice crossed the former location of the hidden platform (i.e., target platform) and other analogous, identically sized locations in the other three quadrants. C, Average distance (averaged across the 1 min probe trial) from the former location of the hidden platform (i.e., target platform) or from other analogous, identically sized locations in the other three quadrants. D, Average swim speed during the 1 min probe trial.