Figure 2. Immunohistochemical detection of activated SFKs in AKs, SCISs, and SCCs.

Sections of actinic keratoses (AK), squamous cell carcinoma in situ (SCIS), and squamous cell carcinoma (SCC) were incubated with pY416 antibody to detect activated SFKs. There is a significantly greater degree of membrane and cytoplasmic staining in the AK, SCIS, and SCC compared to the unremarkable epidermis. Two magnifications of representative biopsies are shown.