Figure 5.
Schematic of progenitor types and lineages in the adult brain SVZ. NSCs in the wall of the lateral ventricles of adult rodents correspond to type B cells (SVZ astrocytes). These cells retain epithelial properties, including the extension of a thin apical process that ends on the ventricle and a basal process ending on blood vessels. B cells give rise to C cells, which correspond to nIPCs. B cells also generate oligodendrocytes through oIPCs. Dashed arrows illustrate hypothetical modes of division: blue for asymmetric and red for symmetric divisions. Investigators do not currently know how many times C cells divide. See Figure 1 for other information. nIPCs, neurogenic intermediate progenitor cells; NSCs, neural stem cells; oIPCs, oligodendrocytic intermediate progenitor cells; SVZ, subventricular zone.