Fig. 1.
P2Y2R structure and domains: the P2Y2R is a seven pass transmembrane G protein-coupled extracellular nucleotide receptor. It is activated equipotently by ATP and UTP and has been shown to be upregulated in response to stress or injury in various cell types. Highlighted features include the consensus RGD integrin-binding domain (in pink), positively-charged amino acid residues known to be involved in ATP/UTP binding (in orange), two consensus PXXP SH3 domain binding sites (in yellow), the FLNa binding site, the intracellular loops that regulate Gq protein binding, and two glycosylation sites