Table 2.
Sensitivity and specificity of question 1 on the Mayo Sleep Questionnaire for PSG-proven RBD*
| +DEB plus +RSWA | NOT +DEB plus +RSWA | ||||
|---|---|---|---|---|---|
| MSQ Q1 - Yes | 79 | 17 | SN | 98% | [95%CI: 0.91–0.99] |
| MSQ Q1 - No | 2 | 49 | SP | 74% | [95%CI: 0.63–0.84] |
| Total | 81 | 66 |
Abbreviations: 95%CI = 95% confidence interval, +DEB=dream enactment behavior by history and/or PSG is present, EMG=electromyographic, MSQ=Mayo Sleep Questionnaire, PSG=polysomnography, Q1=question one, RBD=rapid eye movement sleep behavior disorder, +RSWA=rapid eye movement sleep without atonia is present, SN=sensitivity, SP=specificity
Caveats:
19 patients did not attain REM sleep on their PSG and thus their data was not included
81 (55% of cohort) met established criteria for the diagnosis of RBD
10 patients had equivocal EMG findings in REM sleep are their data are excluded from this analysis; their data were analyzed separately – see text for elaboration
6 patients had RSWA without a clinical history of DEB nor any DEB present on PSG
2 patients had false negative responses; 1 has non-amnestic MCI and over time was found to have PSG evidence of narcolepsy plus RBD, and the other has Alzheimer’s disease features but no history of DEB