Table 2.
In Vivo β-Amyloid Load and Diagnostic Neuropathologic Assessment
| Variable | Participants |
|||||||
|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E | F1 | F2 | F3 | |
| Amyloid load: overall | ||||||||
| Imaging | ||||||||
| Mean cDVR | 0.96 | 1.01 | 1.06 | 1.09 | 1.42 | 1.54 | 1.59 | 1.57 |
| Highest regional DVR | 1.03 | 1.16 | 1.24 | 1.21 | 2.07 | 1.93 | 2.00 | 1.90 |
| Pathologic assessment | ||||||||
| CERAD NP rating | None | Moderate | Moderate | Moderate | Sparse | Moderate | Moderate | Moderate |
| Amyloid angiopathy | No | No | No | Yes | Yes | Yes | Yes | Yes |
| Amyloid load: regional | ||||||||
| Imaging (DVR) | ||||||||
| Orbitofrontal | 0.93 | 0.96 | 0.92 | 1.12 | 1.27 | 1.49 | 1.54 | 1.58 |
| Prefrontal | 0.86 | 0.93 | 0.93 | 1.21 | 1.26 | 1.52 | 1.60 | 1.63 |
| Superior frontal | 0.95 | 0.99 | 1.06 | 1.22a | 1.39 | 1.67 | 1.69 | 1.67 |
| Parietal | 0.94 | 0.96 | 1.07 | 0.94 | 1.42 | 1.40 | 1.44 | 1.42 |
| Lateral temporal | 0.94 | 0.98 | 1.01 | 1.11 | 1.28 | 1.39 | 1.42 | 1.43 |
| Medial temporal | 1.00 | 1.04 | 1.02 | 0.95 | 1.13 | 0.94 | 0.90 | 0.90 |
| Occipital | 1.01 | 1.08 | 1.02 | 1.03 | 1.18 | 1.09 | 1.11 | 1.14 |
| Anterior cingulate | 1.00 | 1.03 | 1.22 | 1.21 | 1.48 | 1.84 | 1.88 | 1.78 |
| Posterior cingulate | 1.03a | 1.16a | 1.24a | 0.91 | 2.07a | 1.93a | 2.00a | 1.90a |
| Pathologic findings | ||||||||
| Middle frontal gyrus | None | Sparse | Moderate | Moderate | Sparse | Sparse | ||
| Inferior parietal gyrus | None | Moderate | Moderate | Sparse | Sparse | Moderate | ||
| Superior and middle temporal gyri | None | Moderate | Sparse | Sparse | Sparse | Moderate | ||
| Neuropathologic assessment | ||||||||
| CERAD rating (overall) | 0 | B | B | B | A | B | ||
| Braak (Stage) | 4 | 3 | 4 | 3 | 4 | 3 | ||
| NIA-Reagan criteria for likelihood of dementia | Not met | Not met | Not met | Intermediate | Not met | Intermediate | ||
| Neuropathologic diagnosis of AD (CERAD) | Normal | Possible AD | Possible AD | Possible AD | Normal | Probable AD | ||
| Imaging–pathologic assessment interval, y | 1.7 | 2.4 | 2.4 | 1.1 | 1.4 | 3.1 | 1.8 | 0.2 |
| Postmortem delay, h | 36 | 13 | 15 | 7.5 | >48 | 22 | ||
| Other pathologic findings | ||||||||
| Lewy bodies | None | None | None | None | Yes | None | ||
| Infarcts | None | No | Yes | None | None | None | ||
| Microinfarcts | Cerebellar cortex | No | No | None | Caudate | None | ||
| Atherosclerosis | Yes | Yes | Yes | Yes | Yes | Yes | ||
Abbreviations: AD, Alzheimer disease; cDVR, cortical distribution volume ratio; CERAD, Consortium to Establish a Registry for AD; DVR, distribution volume ratio; NIA, National Institute on Aging; NP, neuritic plaque.
a
Indicates the highest regional DVR.