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. 2011 Mar 30;31(13):5045–5054. doi: 10.1523/JNEUROSCI.4802-10.2011

Table 1.

Basic characterization of receptors containing concatemers

Combination ACh EC50 (μm)
 5I A85380 response
 10 μm 17β-Estradiol
Mean SE N Mean SE N Mean SE N p
α4&β2 1:8 6.6 1.4 14 1.44 0.06 11 2.56 0.12 7 0.000
α4&β2 8:1 131 11 25 0.19 0.03 9 2.96 0.30 12 0.000
α/β 105 23 18 0.16 0.01 16 0.85 0.06 5 0.047
β/α 121 16 48 0.44 0.04 62 3.17 0.25 6 0.000
α/β&α4 87 8 33 0.14 0.01 29 1.47 0.07 27 0.000
β/α&α4 140 14 43 0.17 0.01 46 3.77 0.20 11 0.000
α/β&β2 2.9 0.6 12 1.84 0.07 16 1.04 0.06 11 0.560
β/α&β2 4.4 0.8 29 1.59 0.07 34 3.73 0.32 7 0.000

The first column names the constructs injected. The next three columns give data on activation by ACh in terms of the EC50 value provided by a fit of the Hill equation. The three columns headed “5I A85380 response” give data on the response to 1 μm 5I A85380 normalized to the response to 1 mm ACh, for that cell. The columns headed “10 μm 17β-Estradiol” give data for the potentiation by 10 μm 17β-estradiol of a response to a low concentration of ACh; the column headed p gives the probability that the potentiation ratio differs significantly from 1 (no effect), by two-tailed t test.