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(A) Under normal condition, p53 has been shown to regulate hematopoietic stem cell quiescence mediated by Gfi-1 and Necdin. It is likely to maintain self-renewal by yet unknown mechanism. (B) Increasing level of stress triggers ATM activation which will increase p53 activation. By downstream mediators such as p21, Puma and Slug, p53 triggers cell cycle arrest, DNA repair or apoptosis.
