Figure 7. dsRNA ONs serve as effective adjuvants for an influenza vaccine.
WT mice were primed and boosted with rNP plus pIC or 540 bp dsRNA (A) or rNP plus 90, 139 or 540 bp dsRNA ONs (B). Controls (dashed lines) include untreated naïve mice, mice treated with rNP alone and mice treated with 540 bp dsRNA alone. Three weeks after the boost mice were challenged with 10 LD50 of influenza virus and survival was monitored thereafter. Asterisks indicate a significant difference in the percentage of survival between naïve and immunized mice (*P<0.05; **P<0.01; ***P<0.001).