Skip to main content
. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: J Immunol. 2011 Feb 15;186(4):2422–2429. doi: 10.4049/jimmunol.1002845

Figure 4. DC activation increases with dsRNA length.

Figure 4

FACS-sorted CD24high and CD11bhigh FL-DC subsets from WT and TLR3−/− mice were stimulated with 25 bp, 60 bp, 90 bp, 139 bp and 540 bp dsRNA, with pIC or were left untreated (Ctrl). After 24 h, CD86 upregulation and cytokine production were determined. pIC and dsRNA ON concentrations were at or near the plateau on dose response curves. Values depicted are means +SEM from 3 independent experiments. * designates significant differences compared to untreated control (*P<0.05; **P<0.01; ***P<0.001), whereas † indicates significant differences between WT and TLR3−/− DC (†P<0.05; ††P<0.01; †††P<0.001).