Figure 2.
SRP across multiple spatial frequencies and contrasts enhances acuity and contrast sensitivity. A, Awake, head-fixed mice were exposed to full-field, phase-reversing sinusoidal grating stimuli across a range of spatial frequencies (0.05, 0.15, 0.3, 0.45, 0.6, and 0.8 cycle/°) at a set oblique orientation over 5 d. VEP amplitude on day 5 (gray circles) and day 1 (white circles) was compared at each spatial frequency to determine spatial acuity for the two orientations (n = 9). Example VEPs are presented for both orientations in the top of the panel above graph points. Calibration: 100 μV, 50 ms. B, Experience-dependent gains in acuity are revealed by normalizing VEPs on day 5 (gray circles) to day 1. C, Mice were repeatedly exposed to a single oblique orientation across a range of contrast values (0, 1.5, 3.125, 6.25, 12.5, 25, 50, and 100% contrast) for 5 d. VEP amplitude was increased across a range of contrasts on day 5 (gray circles) compared with day 1 (white circles). Example waveforms are presented at the top of the panel. D, Experience-dependent gains in contrast sensitivity are revealed by normalizing VEPs on day 5 (gray circles) to day 1. The dotted lines represent noise levels as determined with a static gray screen in both C and D. Error bars are SEM.