FIGURE 1.
A, schematic representation of the effects of retro-inverso peptides. Natural orientation of parent l-amino acid peptide (panel A). Reversed side chain orientation in d-amino acid peptide (panel B). Retro-inverso peptide with restored side chain orientation (panel C). B, CD spectra of retro-inverso VEGF peptide mimic. CD spectroscopy measurements were made of 100 μm peptide solutions in ether water. Spectra characteristic of β-turn is observed by the shifting of θ mimina toward 217 nm. Inversion of the ellipticity in the spectra was result of inverted chirality by using d-amino acid (RI) resulting in a mirror image profile.