Figure 3. Disease-associated differences in splicing of sarcomere genes in diseased compared to control myocardium.
a. Minor variant fraction of TNNI3 and MYH7-1 were measured by RTPCR in control, ICM, DCM, and AS samples (5 per group). b. Minor variant fraction of TNNT2, MYH7-2, and FLNC sarcomere genes were measured by RTPCR in control, ICM, DCM, and AS samples (10 per group). c. LVAD mechanical unloading did not normalize splicing of the four sarcomere genes in heart failure. n=4. NS, not significant. *, P < 0.05, using Welch's t-test with Sidak correction.
