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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: J Invest Dermatol. 2010 Sep 2;131(1):141–149. doi: 10.1038/jid.2010.259

Figure 3. NFKB p65 phosphorylation.

Figure 3

NFKB p65 was over phosphorylated in the skin of Sharpincpdm/Sharpincpdm mutant mice (arrows indicated positive, brown, nuclei). NFKB p65 phosphorylation was decreased by inactivation of Il1rap and especially by bortezomib inhibition in Sharpincpdm/Sharpincpdm mutant mice. Bortezomib did not affect NFKB p65 phosphorylation in skin of control mice. a: Sharpincpdm/Sharpincpdm mutant mice; b: +/+ control; c: l1raptm1Roml/Il1raptm1Roml; d: l1rap+/l1rap+, Sharpincpdm/Sharpincpdm mutant mice; e: Sharpincpdm/Sharpincpdm mutant mice with bortezomib treatment; f: +/+ control with bortezomib treatment. Bar = 5 um.