TABLE 4.
Weight loss, percentage of lung tissue affected, relative lung weights, and virus titers in the lungs of ferrets 4 days after infection with pH1N1
| Group | Immunization |
Wt loss (%) |
Affected lung tissue (%) |
Relative lung wt (%) |
Lung virus titers (TCID50/g of lung)a |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| First | Second | Median | Range | Median | Range | Median | Range | Mean (SD) | nb | |
| 1 | sVacMF59 | pVacc | 10.8 | <0-17 | 5.0 | 0-20 | 0.9 | 0.8-1.3 | 2.7 (1.9) | 4 |
| 2 | sVacMF59 | pVacMF59 | 7.5 | 2-16 | 5.0 | 0-5 | 0.8 | 0.7-0.9 | Negd | 0 |
| 3 | sVac | sVac | 15.1 | 7-33 | 15.0 | 5-30 | 1.2 | 0.8-2.0 | 6.0 (0.6) | 6 |
| 4 | sVac | pVac | 15.6 | 8-23 | 7.5 | 0-20 | 1.0 | 0.7-1.3 | 3.1 (1.8) | 4 |
| 5 | sVac | pVacMF59 | 10.1 | 1-22 | 5.0 | 0-20 | 0.9 | 0.6-1.3 | 1.0 (0.0) | 1 |
| 6 | PBS | pVacMF59 | 13.0 | 6-17 | 5.0 | 0-5 | 1.0 | 0.7-1.3 | Neg | 0 |
| 7 | PBS | PBS | 14.3 | 9-30 | 40.0 | 40-80 | 1.2 | 0.8-1.9 | 5.5 (0.8) | 6 |
a
Data were obtained as described by Del Giudice et al. (8) and are given as a log10 values.
b
n, The number of animals positive for virus isolation from the lungs of six animals per group.
c
Weight loss data were available for 5 of 6 animals.
d
Neg, negative (i.e., all animals tested negative for virus replication in the lungs).