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. Author manuscript; available in PMC: 2011 Mar 28.
Published in final edited form as: Curr Opin Endocrinol Diabetes Obes. 2009 Apr;16(2):156–162. doi: 10.1097/med.0b013e32832922fc

Figure 3. Myeloperoxidase-induced dysfunctional high-density lipoprotein.

Figure 3

Myeloperoxidase (MPO) site specifically binds to apoA-I and produces reactive oxidative species that are responsible for the nitration and chlorination of tyrosine residues within apoA-I. Consequently, the modified high-density lipoprotein (HDL) impairs the ABCA1-dependent cholesterol efflux activity in macrophages.