Fig. 2.
Examples of volumetric (above) and bi-dimensional or area (below) central imaging measures (provided in percentage compared with the smallest measurement in serial MRI scans during a patient's on-study time) and the duration of a patient's “on study” interval. The solid lines represent a patient who progressed early by both volumetric and area criteria (on the same scan) and was called “progressive disease” by the treating institution at the same time. The dashed lines represent a patient who progressed by volumetric measurements on day 210 but never met criteria for progressive disease by bi-dimensional measurements or clinical criteria; he remained in the study and receiving treatment for >103 weeks (725 days) and completed all therapy per protocol. The dotted lines represent the patient who had “pseudo-progression”.