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. 2011 Jan 31;286(13):11211–11217. doi: 10.1074/jbc.M110.185041

TABLE 1.

Changes in the relative mAb1 pE levels in vivo

k is the first order rate constant calculated by averaging the data for two patients at each dosing. IV, intravenously; SC, subcutaneously.

Dosing Heavy chain
 Light chain
k 95% confidence interval k 95% confidence interval
day−1 day−1
100 mg IV 0.00304 0.002734–0.003347 −0.000007 −0.000201–0.000186
300 mg IV 0.00374 0.003133–0.004353 0.000215 0.000135–0.000296
1000 mg IV 0.00332 0.003152–0.003493 0.000261 0.000162–0.000360
300 mg SC 0.00353 0.003324–0.003733 0.000155 −0.000033–0.000342
Average 0.00336 0.00014