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. 2011 Mar 21;192(6):1023–1041. doi: 10.1083/jcb.201012116

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© 2011 Williams et al.

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Figure 2. — MKS/MKSR and NPHP proteins localize at the ciliary TZ. (A) Fluorophore-tagged MKS/MKSR and NPHP proteins localize at the TZ in tail cilia. Each TZ protein signal is overlaid with IFT or other TZ protein signal, as indicated. Bar, 10 µm. (B) MKS-5::tdTomato and MKS-6::GFP localize at the TZ in head cilia. MKS-5 and MKS-6 are overlaid with IFT proteins DYF-11::GFP and XBX-1::tdTomato, respectively. Bar, 10 µm. (C) GFP-tagged MKS-1, MKSR-1, and MKS-6 localize at the base of ciliary axonemes (consistent with the TZ), which are marked by staining with an antibody against polyglutamylated tubulin. Bar, 10 µm. (D) Schematic of MKS/MKSR/NPHP protein localization at the TZ.