Figure 1.
The RP of mdx fibers exhibit reduced ouabain sensitivity that is reversed by exposure to the NF-κB inhibitor PDTC. Shown is the effect of a 30 minute exposure to ouabain (1 mM) on the RP of untreated nondystrophic fibers, untreated mdx fibers, and mdx fibers pretreated and exposed to PDTC. The change in RP was determined for each preparation by subtracting the mean RP obtained after the 30 minute ouabain exposure from that obtained immediately prior to the addition of ouabain. N is the number of TS preparations. *** indicates p<0.001 in comparison to nondystrophic TS.
