TABLE 2.
Competition between indicated agonists (1 μM) for short-term inhibition of AC
Percentage competition was calculated as described under Results (Brinkerhoff et al., 2008) using experimental data shown in Fig. 1. The percentage of competition from three individual experiments was compiled and is presented as mean ± S.E.M.
| Agonist R1 (Receptor) | Agonist R2 (Receptor) | Competition |
|---|---|---|
| % | ||
| DAMGO (MOR) | SNC80 (DOR) | 78 ± 8 |
| DAMGO (MOR) | Nociceptin/OFQ (NOPr) | 97 ± 12 |
| DAMGO (MOR) | UK14,304 (α2AR) | 115 ± 10 |
| DAMGO (MOR) | Clonidine (α2AR) | 106 ± 22 |
| DAMGO (MOR) | CP 55,9140 (CB1) | 121 ± 24 |
| DAMGO (MOR) | 8-OH-DPAT (5-HT1A) | 97 ± 13 |
| UK 14301 (α2AR) | CP 55,9140 (CB1) | 95 ± 19 |
| 8-OH-DPAT (5-HT1A) | Clonidine (α2AR) | 95 ± 16 |
| 8-OH-DPAT (5-HT1A) | CP 55,9140 (CB1) | 83 ± 6 |