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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: J Am Chem Soc. 2011 Feb 28;133(11):4018–4029. doi: 10.1021/ja109679q

Figure 2.

Figure 2

(a,b) Seeded D23N-Aβ1-40 fibril formation monitored by ThT fluorescence for generations 1 (□) and 9 (Δ) under growth conditions A (pH 7.4, 37° C) and B (pH 8.9, 37° C). (c,d) ThT fluorescence intensities for each generation of seeding after 48 hr of fibril growth. (e,f) Negatively stained TEM images for fibrils Ag9 and Bg9, showing the final, homogeneous morphologies produced by repetitive seeding under conditions A and B with 60 min fibril growth in each generation.