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. 2010 Mar 10;35(7):1485–1499. doi: 10.1038/npp.2010.18

Table 6. Comparison Between Controls and Cocaine-Addicted Subjects in Change in BSI After Saline, Physostigmine, and Scopolamine Infusions.

Symptoms Saline [mean (SD)]
 Physostigmine [mean (SD)]
 Scopolamine [mean (SD)]
  Control (n=22) Cocaine (n=23) p-valuea Control (n=22) Cocaine (n=22) p-valuea Control (n=20) Cocaine (n=23) p-valuea
Somatization 0.006±0.08 0.013±0.06 0.39 0.045±0.13 0.103±0.43 0.543 0.186±0.26 0.031±0.11 0.013
Obsessive–compulsive −0.008±0.04 0.023±0.14 0.629 0.000±0.09 −0.060±0.22 0.228 0.025±0.23 −0.007±0.20 0.623
Interpersonal sensitivity −0.023±0.17 0.034±0.12 0.80 −0.023±0.11 −0.034±0.26 0.850 −0.013±0.06 −0.043±0.18 0.463
Depression −0.008±0.04 0.038±0.15 0.19 0.000±0.00 0.023±0.17 0.523 0.000±0.00 −0.073±0.15 0.034
Anxiety −0.008±0.04 0.046±0.11 0.113 0.008±0.11 0.015±0.19 0.879 0.009±0.09 −0.036±0.23 0.410
Hostility 0.000±0.00 0.045±0.11 0.050 0.000±0.00 0.027±0.17 0.447 −0.010±0.05 −0.026±0.07 0.377
Phobic anxiety 0.00±0.00 0.018±0.06 0.155 0.000±0.00 0.000±11 0.999 0.000±0.00 0.026±0.07 0.098
Paranoid ideation 0.000±0.00 0.091±0.33 0.197 −0.036±0.13 0.027±0.16 0.151 −0.020±0.09 −0.000±0.15 0.601
Psychoticism −0.027±0.13 0.009±0.14 0.661 0.000±0.00 0.045±0.14 0.127 −0.030±0.10 −0.017±0.10 0.684
GSI −0.007±0.04b 0.001±0.06 0.602 0.001±0.03 0.019±0.17 0.634 0.022±0.06 −0.020±0.07 0.046
PSDI −0.091±0.43 0.080±0.30 0.919 0.125±0.37 −0.030±0.24 0.103 0.136±0.63 0.052±0.35 0.584
PST −0.136±1.04 0.091±2.83 0.725 0.045±1.40 −0.545±2.99 0.405 0.700±2.74 −0.261±2.24 0.213
a

p-values uncorrected for multiple comparisons.

b

Increase post-infusion relative to pre-infusion.