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Proapoptotic target genes in a list of experimentally validated p53 target genes (Sup. Table 1) are enriched for p53 response elements with spacers and non-CATG core sequences. Statistical significance was calculated by Pearson's Chi-square test. (A) Number of half-sites with a central CATG versus CAAG, CTTG or CTAG sequence in non-versus proapoptotic target genes. (B) Presence of spacer containing response elements in non-versus proapoptotic target genes.
