Figure 3.
Histology of pancreatic lesions identified in elastase-tv-a mice infected with RCAS-PyMT. Areas highlighted by yellow boxes are shown at higher magnification at right. (A,B) Normal adult pancreas. (C,D) PanIN lesion induced in a TSG wild-type mouse. Note shift from a flat cuboidal epithelium (B) to a columnar epithelium with mucinous change (D). (E,F) Acinar carcinoma induced in an elastase-tv-a, Ink4a/Arf null mouse. Arrow indicates a non-neoplastic duct trapped within the tumor. (G,H) Cystadenocarcinoma induced in an Ink4a/Arf null mouse. Note papillary growth pattern of tumor cells into lumen of cyst and the prominent reactive stroma.