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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: J Med Chem. 2008 Aug 8;51(17):5176–5197. doi: 10.1021/jm800113p

Scheme 3a.

Scheme 3a

a (a) Boc2O, cat. DMAP, THF, rt, 16 h, 99%; (b) H2, 10% Pd/C, EtOH, rt, 16 h, 100%; (c) N-(2-pyrimidinyl)-4-hydroxymethylpiperidine, PPh3, DIAD, THF, rt, 16 h; (d) TFA/CH2Cl2, 1:1, rt, 3 h, 92% (two steps).