. 2010 Jul 14;31(2):439–447. doi: 10.1038/jcbfm.2010.103

Table 2. Summary of proposed treatment regimes including estimated peak plasma concentrations and estimated times to reach 100 ng/mL in the CSF.

Regime no.	Bolus (mg)	Infusion rate (mg/h)	Mean predicted peak plasma concentration (ng/mL)	Total dose (mg)	Estimated time taken to reach 100 ng/mL of IL-1RA in CSF (minutes)
1	100	4	34,772	1220	104
2	200	2	41,152	760	141
3	300	2	61,728	860	96
4	400	6	82,304	2080	43
5	500	10	102,880	3300	30

CSF, cerebrospinal fluid; IL, interleukin.