Table 1.
Sample Description
| Cohort | Number of Cases | Number of autopsies | Mean onset age (SD) | Number of Controls | Number of autopsies | Mean age at last exam (SD) | Total | Percent of Ethnic group |
|---|---|---|---|---|---|---|---|---|
| Caucasian Subjects | ||||||||
| ADC | 1,595 | 1,421 | 73 (7.7) | 553 | 134 | 77 (8.7) | 2,148 | 17% |
| ADNI | 286 | 0 | 74 (8.1) | 195 | 0 | 78 (5.4) | 481 | 4% |
| CAMP | 127 | 0 | 79 (7.9) | 105 | 0 | 76 (7.8) | 232 | 2% |
| FHS | 197 | 0 | 83 (6.4) | 2,392 | 0 | 73 (7.5) | 2,589 | 20% |
| UM/VU/MSSM | 1,170 | 370 | 74 (7.7) | 1,169 | 75 | 74 (7.6) | 2,339 | 18% |
| MIRAGE | 560 | 0 | 71 (6.5) | 790 | 0 | 72 (7.1) | 1,350 | 10% |
| NIA LOAD | 993 | 367 | 72 (6.9) | 884 | 45 | 76 (8.4) | 1,877 | 14% |
| OHSU | 187 | 215 | 87 (7.3) | 429 | 461 | 86 (7.2) | 616 | 5% |
| TGEN | 820 | 613 | 80 (8.3) | 517 | 377 | 83 (8.9) | 1,337 | 10% |
| Totals | 5,935 | 2,986 | 7,034 | 1,092 | 12,969 | 100% | ||
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| African American Subjects | ||||||||
| ADC | 61 | 61 | 75 (7.0) | 63 | 63 | 76 (6.2) | 124 | 14% |
| JHU | 221 | 0 | 77 (6.6) | 186 | 0 | 78 (6.6) | 407 | 45% |
| MIRAGE | 180 | 0 | 70 (8.9) | 200 | 0 | 71 (10.0) | 380 | 42% |
| Totals | 462 | 61 | 449 | 63 | 911 | 100% | ||
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| Arab Subjects | ||||||||
| Wadi Ara | 124 | 0 | 78 (7.9) | 142 | 0 | 72 (6.0) | 266 | 100% |
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| Caribbean Hispanic Subjects | ||||||||
| Columbia | 549 | 8 | 80 (8.0) | 544 | 0 | 79 (6.4) | 1,093 | 100% |
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| All Ethnic Groups | ||||||||
| Totals | 7,070 | 3,055 | 8,169 | 1,155 | 15,239 | |||
SD: standard deviation; ADC: Alzheimer Disease Centers cohort; ADNI: Alzheimer Disease Neuroimaging Initiative cohort; FHS.: Framingham Heart Study cohort; UM/VU/MSSM: University of Miami/Vanderbilt University/Mt. Sinai School of Medicine cohort; MIRAGE: Multi Institutional Research on Alzheimer’s Genetic Epidemiology cohort; NIA LOAD: National Institute on Aging Late-onset Alzheimer Disease cohort; OHSU: Oregon Health Sciences University cohort; TGEN: Translational Genomics Research Institute cohort; JHU: Johns Hopkins University cohort. Additional information on all cohorts is provided in the supplementary materials supplied online.