Table 1.
Sleep parameters during the 12-h light and dark phases and across the entire 24-h baseline recording session
| Light Phase |
Dark Phase |
24-h Avg. |
||||
|---|---|---|---|---|---|---|
| Saline | Minocycline | Saline | Minocycline | Saline | Minocycline | |
| Wake (%) | 41 ± 2 | 50 ± 2* | 68 ± 2 | 57 ± 2* | 54 ± 2 | 54 ± 2 |
| NREMS (%) | 48 ± 1 | 40 ± 2* | 27 ± 2 | 35 ± 1* | 37 ± 1 | 38 ± 1 |
| REMS (%) | 11 ± 1 | 9 ± 1 | 6 ± 1 | 8 ± 1 | 9 ± 1 | 9 ± 1 |
| Delta Power (μV2/Hz) | 440 ± 111 | 372 ± 86 | 518 ± 133 | 416 ± 90 | 478 ± 121 | 393 ± 87 |
ANOVAs for repeated measures yielded significant treatment × time of day interaction for wake and NREMS (P < 0.05).
*
P < 0.05, saline vs. minocycline with Bonferroni correction.