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. 2011 Jan 27;22(2):132–136. doi: 10.1021/bc1004685

Figure 2.

Figure 2

In situ bridging of somatostatin. (a) The in situ protocol. (b) LCMS data showing the effect of varying TCEP equiv on the in situ bridging of somatostatin using dibromomaleimide 1 (5 equiv) after 1 h. (c) LCMS data showing the effect of varying TCEP equiv on the in situ bridging of somatostatin using dithiophenolmaleimide 5 (5 equiv) after 1 h. (d) LCMS data over 2 h showing the in situ bridging of somatostatin using the optimized conditions of dithiophenolmaleimide 5 (5 equiv) and TCEP (3 equiv).