Table 2. Voxel-Based Clusters in Which Adolescents at Familial Risk for Depression had Significantly Lower Fractional Anisotropy (p<0.001, uncorrected; p<0.05, after FDR correction of small volume) Compared with Controls.
| Control (n=13) | High risk (n=18) | Statistics | p-value | |
|---|---|---|---|---|
| Cingulum (left) | 0.41 (0.05) | 0.34 (0.03) | 5.12 | 0.0001 |
| Superior longitudinal fasciculus | ||||
| Left | 0.52 (0.03) | 0.45 (0.03) | 5.57 | 0.0001 |
| Right | 0.49 (0.05) | 0.43 (0.04) | 3.49 | 0.0008 |
| UNC-IFO | ||||
| Left | 0.62 (0.05) | 0.55 (0.04) | 3.79 | 0.0003 |
| Right | 0.59 (0.05) | 0.51 (0.06) | 3.65 | 0.0005 |
| Splenium of corpus callosum | 0.72 (0.07) | 0.57 (0.09) | 4.52 | 0.0001 |
Abbreviation: UNC-IFO, combined uncinate and inferior fronto-occipital fasciculus.
Data in parentheses reflect SD.