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. Author manuscript; available in PMC: 2012 Feb 4.
Published in final edited form as: Cell Stem Cell. 2011 Feb 4;8(2):188–199. doi: 10.1016/j.stem.2010.12.006

Figure 7. Model for the role of Keap 1 and Nrf2/CncC in the control of ISC proliferation.

Figure 7

Nrf2/CncC induces anti-oxidant gene expression, promoting a reducing environment in ISCs that ensures cytoprotection and limits ISC proliferation. Keap1-mediated inhibition of CncC is critical to allow proliferation of ISCs in response to stress and mitogenic signaling. By limiting ISC proliferation, the Keap1/CncC signaling module thus balances the need for ISC-mediated tissue regeneration with the necessity for proliferation control, promoting proliferative homeostasis in the intestinal epithelium.