. Author manuscript; available in PMC: 2011 Feb 7.

Published in final edited form as: Am J Physiol Renal Physiol. 2006 Oct 17;292(3):F1044–F1053. doi: 10.1152/ajprenal.00175.2006

Table 2.

Drug effects on tonic and bursting EUS activity (area, mV-ms) during bladder filling or voiding in rats with intact-SC and chronic SCT at T8 –9 and L3– 4

	Intact-SC (n = 10)		Chronic T8–9 SCT (n = 6)		Chronic L3–4 SCT (n = 7)
	Tonic Activity During Filling	EUS Bursting During Voiding	Tonic Activity During Filling	EUS Activity During Voiding	Tonic Activity During Filling	Tonic Activity During Voiding
Before drugs	21.4±0.6	98.1±2.6	16.2±0.1	77.7±1.5^(a)	14.6±0.5	49.2±0.2
8-OH-DPAT	43.7±1.2^*	165.4±4.1^*	36.1±1.1^*^(d)	122.6±3.8^* ^(b, ^d)	37.4±0.9^*	119.4±2.6^*
WAY100635	18.9±0.4^†	95.6±1.9^†	20.3±0.5^† ^(d)	88.7±7.3^† ^(c, ^d)	19.3±0.4^†	72.6±3.9^*^†

Values are means ± SE. EUS, external urethral sphincter.

^(a)

EUS tonic activity (n = 4) and EUS bursting activity (n = 2).

^(b)

EUS bursting activity.

^(c)

EUS tonic activity.

^(d)

Drugs were tested in 5 of the chronic T8–9 SCT rats.

P < 0.05, significantly increased compared with control before drugs.

^†

P < 0.05, significantly reduced compared with records after 8-OH-DPAT.