Fig. 4.
Effects of serotonergic drugs on the bladder (top left traces), EUS EMG activity (bottom left traces), and pelvic-EUS reflex (right traces) in a rat with chronic L3–4 SCT during bladder filling and repeated voiding. A1, B1, C1: in each record, EUS EMG activity is shown at a slow time base (middle trace) and an expanded time base (bottom trace) of the sequence of recording indicated by the brackets (1, 2, 3) in the middle traces. A1: before drug treatment, the bladder exhibited rhythmic micturition contractions during bladder filling. At the peak of the contractions, tonic EUS activity was markedly enhanced. EUS bursting activity did not occur. B1: 8-OH-DPAT enhanced tonic EUS activity but did not unmask EUS bursting. C1: WAY100635 reversed the effect of 8-OH-DPAT on tonic EUS activity. A2–C2: the ER remained, but the LR was absent in the chronic L3–4 SCT rat. The ER was not affected by drugs. Dot, electrical stimulation (6 V, 1.0 Hz, pulse width 0.05 ms).