. 2010 Oct 24;68(4):651–659. doi: 10.1007/s00018-010-0563-8

Table 1.

Zebrafish photoreceptor degeneration mutants

Mutant name/allele	Causal gene	Protein function	Phenotype	Gene/mutation identification
pob ^a1	Partial optokinetic response b; GeneID: 406826	Unknown	Red cone degeneration 4 dpf	[74]
pde6c ^w59 els ^rw76a	Phosphodiesterase 6c; GeneID: 5146	Hydrolysis of cGMP during phototransduction	Cone degeneration 4 dpf onward	[5, 6]
ovl ^tz288b	Intraflagellar transport (Ift) 88; GeneID: 321855	Intraflagellar transport	Photoreceptor degeneration 4 dpf	[18]
nrf1 ^hi39a	Nuclear respiratory factor 1; GeneID: 64604	Transcription factor	Photoreceptor degeneration 3 dpf	[75]
pwi ^hi1482	Tryptophan rich basic protein; GeneID: 335756	Unknown	Photoreceptor degeneration 2–3 dpf	[19]
ift172 ^hi2211	Ift172; GeneID: 432389	Intraflagellar transport	Photoreceptor degeneration 4 dpf	[19]
ift57 ^hi3417	Ift57; GeneID: 414929	Intraflagellar transport	Photoreceptor degeneration 4 dpf	[19]
elipsa^m649; elipsa^tp49d	TNF receptor-associated factor 3 interacting protein 1; GeneID: 393572	Component of IFT particle B	Photoreceptor degeneration 4 dpf	[21]
ako ^jj50	Dynactin 2 (dynamitin); GeneID: 394141	Intracellular organelle transport	Photoreceptor degeneration 3 dpf	[2]
mok^s309; mok^m632	Dynactin 1a (p150); GeneID: 407638	Intracellular organelle transport	Photoreceptor degeneration 3 dpf	[1, 76]
flr ^m477	Fleer, TPR repeat protein 30; GeneID: 797829	Tubulin polyglutamylation	Photoreceptor degeneration 4 dpf	[20]
syu^t4+/−; syu^tbx+/−	Shha, sonic hedgehog a; GeneID: 30269	Maintenance/survival of the cones in the adult retina	Slow adult degeneration	[23]
rep1 ^ru848	Rab escort protein-1; GeneID: 402,935	Directs rab protein movement	Photoreceptor degeneration 4 dpf	[77]

dpf days post fertilization