TABLE 2.
Characteristics of patients and Candida sp. isolates responsible for incident fungemia according to recorded or not recorded recent exposured to fluconazole or caspofungin
| Group and characteristic | Recent exposure to fluconazole |
Recent exposure to caspofungin |
||||
|---|---|---|---|---|---|---|
| None recorded (n = 2,305) | Recorded (n = 136) | P | None recorded (n = 2,391) | Recorded (n = 50) | P | |
| Patients | ||||||
| Mean age (yr) | 56.9 (56.1-57.8)c | 50.7 (47.0-54.5) | <0.001 | 56.9 (56.0-57.7) | 42.7 (36.7-48.6) | <0.001 |
| Male gendera | 1,392/2,305 (60.4) | 78/136 (57.4) | 0.528 | 1,435/2,391 (60.0) | 35/50 (70.0) | 0.189 |
| Hematological malignancya | 411/2,305 (17.8) | 31/136 (22.8) | 0.168 | 414/2,391 (17.3) | 28/50 (56.0) | <0.001 |
| Intensive care unita | 1,073/2,305 (46.6) | 80/136 (58.8) | 0.006 | 1,133/2,391 (47.4) | 20/50 (40.0) | 0.320 |
| Central venous cathetera | 1,723/2,305 (74.8) | 115/136 (84.6) | 0.010 | 1,793/2,391 (75.0) | 45/50 (90.0) | 0.012 |
| After diagnosis of fungemia, prescription ofa: | ||||||
| Fluconazole | 1,233/1,938 (63.6) | 43/129 (33.3) | <0.001 | 1,269/2,022 (62.8) | 7/45 (15.6) | <0.001 |
| Caspofungin | 393/1,938 (20.3) | 52/129 (40.3) | <0.001 | 424/2,022 (21.0) | 21/45 (46.7) | <0.001 |
| Death before day 30a | 859/2,185 (39.3) | 54/134 (40.3) | 0.856 | 892/2,271 (39.3) | 21/48 (43.8) | 0.552 |
| Early death (<day 8)a | 481/846 (56.9) | 26/53 (49.1) | 0.318 | 497/878 (56.6) | 10/21 (47.6) | 0.506 |
| Isolatesb | ||||||
| Mixed infectiona | 75/2,305 (3.3) | 3/136 (2.2) | 0.800 | 77/2,391 (3.2) | 1/50 (2.0) | 1.000 |
| Non-C. albicans speciesa | 1,107/2,377 (46.6) | 89/139 (64.0) | <0.001 | 1,157/2,465 (46.9) | 39/51 (76.5) | <0.001 |
| C. glabrata isolatesa | 393/2,377 (16.5) | 35/139 (25.2) | 0.011 | 413/2,465 (16.8) | 15/51 (29.4) | 0.023 |
| Geometric mean MIC (mg/liter) for the isolate causing fungemia | ||||||
| Fluconazole | 0.77 (0.71-0.83)c | 2.14 (1.51-3.04) | <0.001 | 0.80 (0.74-0.86) | 2.17 (1.23-3.82) | <0.001 |
| Caspofungin | 0.07 (0.07-0.08)c | 0.08 (0.07-0.09) | 0.199 | 0.07 (0.07-0.07) | 0.17 (0.13-0.23) | <0.001 |
| Episodes due to at least one isolate with decreased susceptibility toa: | ||||||
| Fluconazole | 452/2,305 (19.6) | 47/136 (34.6) | <0.001 | 480/2,391 (20.1) | 19/50 (38.0) | 0.004 |
| Caspofungin | 121/1,854 (6.5) | 10/106 (9.4) | 0.231 | 119/1,910 (6.2) | 12/51 (24.0) | <0.001 |
a
The data indicate the number of individuals or isolates for whom the corresponding information was available/total number in the group (%).
b
The total number of isolates studied during incident candidemia was 2,516.
c
Values in parentheses in this row are 95% CIs.
d
Recent exposure was <30 days prior to diagnosis of fungemia.