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Nlrp3−/− mice exhibit enhanced susceptibility to DSS-induced colitis as exhibited by accelerated weight loss (A); reduced hematocrit (B); increased colonic MPO (C). Nlrp3−/− mice exposed to DSS exhibited significantly more inflammation, elevated damage score and overall magnitude of ulceration (D-E; Inflammation score ×10), which is evident in colonic sections stained with H&E. N=8-12; * denotes p<0.05 compared to WT mice; ** denotes p<0.005 compared to WT mice.
